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Description
Since the enormously successful first edition of Forensic DNA Typing was published, the Human Genome Project has published a draft sequence of the human genome and completed the finished reference sequence. The advent of modern DNA technology has resulted in the increased ability to perform human identity testing desirable in a number of situations including the determination of perpetrators of violent crime such as murder and rape, resolving unestablished paternity, and identifying remains of missing persons or victims of mass disasters. The technology has been utilized in identifying remains from victims of the World Trade Center twin towers collapse following the terrorist attacks of September 11, 2001, the President Clinton-Monica Lewinsky scandal, and the identification of the remains in the Tomb of the Unknown Soldier. Indeed, our perceptions of history have been changed with DNA evidence that revealed Thomas Jefferson fathered a child by one of his slaves. This book examines the science of current forensic DNA typing methods by focusing on the biology, technology, and genetic interpretation of short tandem repeat (STR) markers, which encompass the most common forensic DNA analysis methods used today. Ten new chapters have been added to accommodate the explosion of new information since the turn of the century.
Contents
Ch. 1: Overview & History of DNA Typing Ch. 2: DNA Biology Review Ch. 3: Sample Collection, DNA Extraction, and DNA Quantitation Ch. 4: The Polymerase Chain Reaction (DNA Amplification) Ch. 5: Commonly Used Short Tandem Repeat Markers and Commercial Kits Ch. 6: Biology of STRs Ch. 7: Forensic Issues Ch. 8: Single Nucleotide Polymorphisms & Other Bi-allelic Markers Ch. 9: Y-Chromosome DNA Testing Ch. 10: Mitochondrial DNA Analysis Ch. 11: Non-Human DNA and Microbial Forensics Ch. 12: DNA Separation Methods Ch. 13: DNA Detection Methods Ch. 14: Instrumentation for STR Typing Ch. 15: STR Genotyping Issues Ch. 16: Laboratory Validation Ch. 17: New Technologies, Automation, and Expert Systems Ch. 18: CODIS and DNA Databases Ch. 19: Basic Genetic Principles, Statistics, & Probability Ch. 20: STR Population Database Analyses Ch. 21: Profile Frequency Estimates, Likelihood Ratios & Source Attribution Ch. 22: Approaches to Statistical Analysis of Mixtures and Degraded DNA Ch. 23: Kinship and Parentage Testing Ch. 24: Mass Disaster DNA Victim Identification App I: Reported STR Alleles App II: Population Data-STR Allele Frequencies App. III: Suppliers of DNA Analysis Supplies App. IV: DAB QA Standards App. V: DAB Recommendations on Statistics App. VI: NRC II Recommendations App. VII: Example DNA Cases
Hardbound, 688 pages, publication date: FEB-2005
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